FHL3 differentially regulates the expression of MyHC isoforms through interactions with MyoD and pCREB
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- 作者：Yunxia Zhang ; Wentao Li ; Mingfei Zhu ; Yuan Li ; Zaiyan Xu ; xuzaiyan@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Bo Zuo ; zuobo@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：MyHC ; myosin heavy chain ; FHL ; four and half LIM domain protein ; CRE ; cyclic AMP-responsive element ; CREB ; cAMP-response-element-binding protein ; PKA ; cAMP-activited protein kinase A ; MyoG ; myogenin ; MyoD ; myogenic differentiation 1 ; SDS ; Sodium Dodecyl Sulfate ; cDNA ; complementary DNA ; siRNA ; small hairpin RNA ; PCR ; polymerase chain reaction ; MRFs ; myogenic regulatory transcription factors ; IGFs ; insulin-like growth factors ; CaN-NFAT ; calcineurin-nuclear factor of activated T cells ; C/EBP-δ ; CC
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：28
- 期：1
- 页码：60-73
- 全文大小：2182 K
文摘
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FHL3 regulates the expression of MyHC isform genes.
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FHL3 inhibits the expression of MyHC 1/slow by MyoD.
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CREB enhances MyHC 2a prompter activity and increases the expression of MyHC 2a.
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FHL3 promotes the expression of MyHC 2a by interaction with pCREB