Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration
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- 作者：Daniela Fiorea ; c ; 1 ; daniela.fiore@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Robert N. Judsona ; b ; 1 ; robert.judson@stemcell.com" class="auth_mail" title="E-mail the corresponding author ; Marcela Lowa ; b ; mlow@brc.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Sunny Leea ; leesunny.96@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Erica Zhanga ; zxy_ez_lz@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Claudia Hopkinsa ; claudia.i.hopkins@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Peter Xua ; z.xu@alumni.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Andrea Lenzic ; andrea.lenzi@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Fabio M.V. Rossia ; b ; 2 ; fabio@brc.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Dario R. Lemosa ; b ; 2 ; dario@brc.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; dlemavo@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：FAPs ; fibro/adipogenic progenitors ; ECM ; extracellular matrix ; MP ; myogenic progenitor cells ; TA ; tibialis anterior muscle ; RTK ; receptor tyrosine kinase ; TKIs ; tyrosine kinase inhibitors ; (NTX) ; notexin ; (MyoG) ; Myogenin
- 刊名：Stem Cell Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：17
- 期：1
- 页码：161-169
- 全文大小：1996 K
文摘
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RTK signaling drives damage-induced FAP proliferation and differentiation.
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RTK inhibition impairs fibrogenesis and myogenesis in regenerating skeletal muscle.
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FAP expansion stimulates satellite cell proliferation.