Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet
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- 作者：Woo Young Jang ; Ki Beom Bae ; Sung Hyun Kim ; Dong Hun Yu ; Hei Jung Kim ; Young Rae Ji ; Seo Jin Park ; Si Jun Park ; Min-Cheol Kang ; Ja In Jeong ; Sang-Joon Park ; Sang Gyu Lee ; Inkyu Lee ; Myoung Ok Kim ; Duhak Yoon ; Zae Young Ryoo
- 关键词：Jazf1 ; Juxtaposed with another zinc finger protein 1 ; TR4 ; testicular orphan nuclear receptor 4
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：14 February, 2014
- 年：2014
- 卷：444
- 期：3
- 页码：296-301
- 全文大小：1355 K
文摘
Jazf1 is a 27 kDa nuclear protein containing three putative zinc finger motifs that is associated with diabetes mellitus and prostate cancer; however, little is known about the role that this gene plays in regulation of metabolism. Recent evidence indicates that Jazf1 transcription factors bind to the nuclear orphan receptor TR4. This receptor regulates PEPCK, the key enzyme involved in gluconeogenesis. To elucidate Jazf1鈥檚 role in metabolism, we fed a 60% fat diet for up to 15 weeks. In Jazf1 overexpression mice, weight gain was found to be significantly decreased. The expression of Jazf1 in the liver also suppressed lipid accumulation and decreased droplet size. These results suggest that Jazf1 plays a critical role in the regulation of lipid homeostasis. Finally, Jazf1 may provide a new therapeutic target in the management of obesity and diabetes.