Phorbol-12-myristate-13-acetate (PMA) mediated transcriptional regulation of Oncostatin-M
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- 作者：Srimoyee Mukherjee ; Sumita Sengupta (Bandyopadhyay) ; ssbmbg@caluniv.ac.in" class="auth_mail" title="E-mail the corresponding author ; bandyopas@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：PMA ; phorbol 12-myristate 13-acetate ; OSM ; Oncostatin-M ; IL-6 ; interleukin 6 ; C/EBP ; CCAAT-enhancer binding protein ; CHOP ; C/EBP homologous protein ; hnRNA ; hetero nuclear RNA
- 刊名：Cytokine
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：88
- 期：Complete
- 页码：209-213
- 全文大小：1007 K
文摘
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PMA induces transcriptional upregulation of Oncostatin-M in U937 cells.
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A proximal region (CCAAT) of osm promoter is the PMA-responsive element.
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PMA promotes increased expression of C/EBP-β and subsequent binding to CCAAT.
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C/EBP-β inhibition results in consequent expression of CHOP and mutual association.
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C/EBP-β knockdown and inhibition cause abrogated transcription through CCAAT box.