Glial cell response after aneurysmal subarachnoid hemorrhage — Functional consequences and clinical implications
详细信息 查看全文
- 作者：Bart J. van Dijka ; b ; Mervyn D.I. Vergouwenb ; Myrna M. Kelfkensa ; Gabriel J.E. Rinkelb ; Elly M. Hola ; c ; d ; e.m.hol-2@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADAMTS-13 ; a disintegrin and metalloproteinase with a thrombospondin type 1 motif ; member 13 ; AQP1/4 ; Aquaporin 1/4 ; BBB ; Blood Brain Barrier ; BK ; Big Potassium ; CSD ; cortical spreading depression ; CSF ; cerebrospinal fluid ; DCI ; delayed cerebral ischemia ; EBI ; early brain injury ; ERK1/2 ; Extracellular signal-regulated protein kinases 1 and 2 ; ET-1 ; Endothelin-1 ; GABA ; γ-aminobutyric acid ; GFAP ; Glial fibrillary acidic protein ; Gln ; Glutamine ; GLT-1 ; Glutamate Transporter-1 ; GSN ; Gelsolin ; HMGB1
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：1862
- 期：3
- 页码：492-505
- 全文大小：1104 K
文摘
- •
Aneurysmal subarachnoid hemorrhage (SAH) is a severe type of stroke.
- •
SAH can cause early brain damage, delayed cerebral ischemia and cognitive impairment.
- •
Glial response after SAH is both beneficial and detrimental for brain functioning.
- •
Sustained glial response may contribute to cognitive impairment after SAH.