Shikonin induces apoptosis of lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling antagonized by p300
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- 作者：Yun-Ji Jeunga ; d ; 1 ; Han-Gyeul Kima ; c ; 1 ; Jiwon Ahna ; Ho-Joon Leea ; Sae-Bhom Leea ; Misun Wona ; Cho-Rock Junga ; Joo-Young Ima ; Bo-Kyung Kima ; Seung-Kiel Parkd ; Myung Jin Sonb ; c ; mjson@kribb.re.kr" class="auth_mail" title="E-mail the corresponding author ; Kyung-Sook Chunga ; c ; kschung@kribb.re.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Shikonin-induced apoptosis ; AKT ; p300 ; FOXO3a ; EGR1 ; SIRT1
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：1863
- 期：11
- 页码：2584-2593
- 全文大小：1874 K
文摘
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Shikonin isolated Lithospermum erythrorhizon has antitumorigenic properties.
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Inhibition of AKT by shikonin led to phosphorylation and activation of FOXO3a.
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Nuclear FOXO3a induced Bim upregulation and lung cancer cell apoptosis via EGR1.
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p300 and SIRT1 regulate FOXO3a activity through acetylation or de-acetylation.
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Shikonin induces lung cancer cell apoptosis via FOXO3a/EGR1/SIRT1 signaling.