Shikonin isolated Lithospermum erythrorhizon has antitumorigenic properties.
Inhibition of AKT by shikonin led to phosphorylation and activation of FOXO3a.
Nuclear FOXO3a induced Bim upregulation and lung cancer cell apoptosis via EGR1.
p300 and SIRT1 regulate FOXO3a activity through acetylation or de-acetylation.
Shikonin induces lung cancer cell apoptosis via FOXO3a/EGR1/SIRT1 signaling.