Cu²⁺-selective ratiometric fluorescence signaling probe based on the hydrolysis of dansylhydrazine

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• 作者：Myung Gil Choi ; Jieun Kim ; Ja Min Hong ; In Jung Chang ; Sangdoo Ahn ; Suk-Kyu Chang ; ^{skchang@cau.ac.kr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：WAZWAZXWPDTCKG-UHFFFAOYSA-N ; KPQYDVAFRDWIBW-UHFFFAOYSA-N
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：2 March 2016
• 年：2016
• 卷：57
• 期：9
• 页码：975-978
• 全文大小：721 K

文摘

A simple Cu²⁺-selective ratiometric fluorescence signaling probe based on the hydrolysis of dansylhydrazine was developed. Dansylhydrazine 1 showed prominent ratiometric fluorescence signaling behavior toward Cu²⁺ ions in a 50% aqueous (pH 7.4) acetonitrile solution. The ratiometric signaling behavior was due to the Cu²⁺-assisted hydrolysis of the yellow-colored fluorescent dansylhydrazine to strongly blue-fluorescent dansyl acid. The Cu²⁺-selective signaling of probe 1 was not affected by the presence of biologically important metal ions. The ratiometric signaling of Cu²⁺ by 1 was possible with a detection limit of 6.0 × 10⁻⁸ M (3.8 ppb). In addition, the signaling of Cu²⁺ in biological samples using synthetic urine was also tested.