CPF induces apoptotic and necrotic cell death on basal forebrain cholinergic neurons. CPF could induce cell death through extrinsic pathway. Cell death is partially mediated by AChE overexpression. CPF LOATEL was at least 100-fold lower than the concentration needed to AChE inhibition. KChIP1 overexpression after CPF exposure could be a protective mechanism against necrosis.