α4 nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior
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- 作者：Masatoshi Indena ; Kazuyuki Takatab ; Daijiro Yanagisawac ; Eishi Ashiharab ; Ikuo Tooyamac ; Shun Shimohamad ; Yoshihisa Kitamurab ; e ; yo-kita@fc.ritsumei.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Galantamine ; Dopamine ; Parkinson's disease ; Nicotinic acetylcholine receptor ; 6-Hydroxydopamine
- 刊名：Neurochemistry International
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：94
- 期：Complete
- 页码：74-81
- 全文大小：2281 K
文摘
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Galantamine plus nomifensine induced the ipsilateral rotation in the 6-OHDA-injected rats.
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α4 nAChR highly expressed in dopaminergic terminals of the striatum.
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Dihydroxy-β-erythroidine significantly inhibited galantamine-induced rotations.
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ABT-418 induced the ipsilateral rotational behavior.
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Galantamine possesses the property of the dopamine release through α4 nAChR.