Protective effects of ψ taraxasterol 3-O-myristate and arnidiol 3-O-myristate isolated from Calendula officinalis on epithelial intestinal barrier

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• 作者：Stefano Dall'Acqua^a ; ^{stefano.dallacqua@unipd.it" class="auth_mail" title="E-mail the corresponding author} ; Daniela Catanzaro^a ; Veronica Cocetta^a ; Nadine Igl^b ; Eugenio Ragazzi^a ; Maria Cecilia Giron^a ; Laura Cecconello^a ; Monica Montopoli^a
• 关键词：Triterpene ; Calendula officinalis ; CaCo-2 cell monolayers ; Intestinal inflammation ; TEER ; ROS
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：109
• 期：Complete
• 页码：230-235
• 全文大小：933 K

文摘

The triterpene esters ᴪ taraxasterol-3-O-myristate (boldFont">1) and arnidiol-3-O-myristate (boldFont">2) were tested for their ability to protect epithelial intestinal barrier in an in vitro model. Their effects on ROS production and on trans-epithelial resistance were investigated on CaCo-2 cell monolayers both in basal and stress-induced conditions. Both compounds were able to modulate the stress damage induced by H₂O₂ and INFγ + TNFα, showing a potential use as model compounds for the study of new therapeutic agents for intestinal inflammations.