The natural compound silvestrol is a potent inhibitor of Ebola virus replication

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• 作者：Nadine Biedenkopf^a ; ^d ; ¹ ; Kerstin Lange-Grü ; nweller^b ; ¹ ; Falk W. Schulte^b ; Aileen Weiß ; er^b ; Christin Mü ; ller^c ; ^d ; Dirk Becker^a ; ^d ; Stephan Becker^a ; ^d ; Roland K. Hartmann^b ; Arnold Grü ; nweller^b ; ^{gruenwel@staff.uni-marburg.de}
• 关键词：Ebola ; Silvestrol ; eIF4A helicase ; Translation inhibition ; Primary macrophages ; PIM1
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：Complete
• 页码：76-81
• 全文大小：949 K
• 卷排序：137

文摘

The rocaglate silvestrol, a specific eIF4A helicase inhibitor, is a potent antiviral compound to treat Ebola infections. Silvestrol inhibits EBOV in human primary macrophages at low nanomolar concentrations. Silvestrol is not toxic in vitro and in vivo at concentrations of effective antiviral activity. Inhibition of cap-dependent translation initiation is a potent antiviral strategy.