Multipotent mesenchymal stem cells from adult human eye conjunctiva stromal cells

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• 作者：Samad Nadri ; Masoud Soleimani ; Jafar Kiani ; Amir Atashi ; Reza Izadpanah
• 关键词：conjunctiva stromal cells ; mesenchymal stem cells ; human ; multipotent differentiation
• 刊名：Differentiation
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：76
• 期：3
• 页码：223-231
• 全文大小：560 K

文摘

Identification of mesenchymal stem cells (MSCs) derived from alternative sources has provided an exciting prospect for intensive investigation. This work focused on characterizing a new source of MSCs from stromal cells from human eye conjunctiva. In this study, after conjunctiva biopsies and culture of stromal segment of this tissue, fibroblast-like (SH2⁺, SH3⁺, CD29⁺, CD44⁺, CD166⁺, CD13⁺) human stromal cells, which can be differentiated toward the osteogenic, adipogenic, chondrogenic, and neurogenic lineages, were obtained. These cells expressed Oct-4, Nanog, Rex-1 genes, and some lineage-specific markers like cardiac actin and Keratin. Taken together, the results indicate that conjunctiva stromal-derived cells are a new source of multipotent MSCs and despite originating from an adult source, they express undifferentiated stem cell markers.