Cardioprotective and hepatoprotective effects of Citrus hystrix peels extract on rats model

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• 作者：Herwandhani Putri ; Standie Nagadi ; Yonika Arum Larasati ; Nindi Wulandari ; Adam Hermawan ; ^{adam_apt@ugm.ac.id}
• 关键词：Citrus hystrix D.C. ; Cardiohepatoprotector ; Histopathology ; Chemoterapy
• 刊名：Asian Pacific Journal of Tropical Biomedicine
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：3
• 期：5
• 页码：371-375
• 全文大小：554 K

文摘

Objective

To observe the combination effect of doxorubicin and m>Citrus hystrixm> (kaffir lime's) peel ethanolic extract (ChEE) on blood serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity and cardio-hepato-histopathology of female Sprague Dawley rats.

Methods

Doxorubicin and ChEE (5 rats per group) were administered in five groups of 3 rats each for 11 d. Group I: doxorubicin (dox) 4.67 mg/kg body weight; Group II: dox+ChEE 500 mg/kg body weight; Group III: dox+ChEE 1?000 mg/kg body weight; Group IV: ChEE 1?000 mg/kg body weight; Group V: untreated (control).

Results

ChEE repaired cardiohistopathology profile of doxorubicin induced cardiotoxicity and hepatotoxicity rats, but did not repair neither hepatohistopathology profile nor reduce serum activity of ALT and AST.

Conclusion

ChEE has potency to be developed as cardioprotector agent in chemotherapy.