Reliability of measuring regional callosal atrophy in neurodegenerative diseases

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• 作者：Jeroen Van Schependom ; MSc Eng ; PhD^a ; ^c ; ^{Jeroen.Van.Schependom@vub.ac.be} ; Saurabh Jain ; MSc Eng^b ; ^{Saurabh.jain@icometrix.com} ; Melissa Cambron ; MD^a ; ^{Melissa.cambron@uzbrussel.be} ; Anne-Marie Vanbinst ; MD^c ; ^{AnneMarie.Vanbinst@uzbrussel.be} ; Johan De Mey ; MD ; PhD^c ; ^{Johan.Demey@uzbrussel.be} ; Dirk Smeets ; MSc Eng ; PhD^b ; ^{Dirk.Smeets@icometrix.com} ; Guy Nagels ; MD ; PhD ; MSc Eng^a ; ^d ; ^e ; ^{Guy.Nagels@vub.ac.be}
• 关键词：Corpus callosum segmentation ; Biomarker ; Repeatability ; Reproducibility ; Multiple sclerosis ; Alzheimer's disease ; Corpus callosum thickness profile
• 刊名：NeuroImage: Clinical
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：12
• 期：Complete
• 页码：825-831
• 全文大小：638 K
• 卷排序：12

文摘

A completely automated segmentation of the Corpus Callosum Both traditional features and the thickness profile using Laplace's equation are calculated. Excellent reproducibility and accuracy in healthy controls Excellent reproducibility and accuracy in Alzheimer's Dementia and Multiple Sclerosis patients Excellent inter-scanner reliability enabling the pooling of multi-center data