Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the Periphery
详细信息 查看全文
- 作者：Katherine Nutsch
- 关键词：peripheral regulatory T cells ; pTreg ; commensal microbiota ; TGFβ ; CNS1 Foxp3 ; Notch2-dependent dendritic cells
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：27 September 2016
- 年：2016
- 卷：17
- 期：1
- 页码：206-220
- 全文大小：5261 K
文摘
- •
- <p id="p0010">Rapid Treg cell selection to commensals occurs in the distal mesenteric lymph nodep>
- •
- <p id="p0015">TGF-β receptor signaling is not a “master” specifier of Treg versus effector selectionp>
- •
- <p id="p0020">CNS1 deficiency in Foxp3 delays, but does not abrogate, Treg cell selectionp>
- •
- <p id="p0025">Notch2-dependent dendritic cells are involved in Treg cell selectionp>