Clinical value of Tubex™ and Typhidot® rapid diagnostic tests for typhoid fever in an urban community clinic in Bangladesh
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- 作者：Aliya Naheed ; Pavani K. Ram ; W. Abdullah Brooks ; Eric D. Mintz ; Md. Anowar Hossain ; Michele M. Parsons ; Stephen P. Luby ; Robert F. Breiman
- 关键词：Tubex™ ; Typhidot® ; Typhoid fever ; Salmonella Typhi ; Bangladesh
- 刊名：Diagnostic Microbiology and Infectious Disease
- 出版年：2008
- 出版时间：August 2008
- 年：2008
- 卷：61
- 期：4
- 页码：381-386
- 全文大小：120 K
文摘
Tubex™ and Typhidot®, rapid tests for typhoid fever, performed well in evaluations conducted in hospital settings among patients with culture-confirmed typhoid fever. We evaluated these tests in a community clinic in Bangladesh. Blood samples were obtained from 867 febrile patients for culture, Typhidot® and Tubex™ tests. Considering the 43 blood culture-confirmed cases of typhoid fever as typhoid positive and the 24 other confirmed bacteremia cases as typhoid negative, Tubex™ was 60 % sensitive and 58 % specific, with 90 % positive and 58 % negative predictive values (NPVs); Typhidot® was 67 % sensitive and 54 % specific, with 85 % positive and 81 % NPVs. When blood culture-negative patients and other bacteremia cases together were considered typhoid negative, positive predictive values were only 14 % for Tubex™ and 13 % for Typhidot®, increasing to only 38 % and 20 % when restricted to patients with ≥7 days of fever. We conclude that the value of Tubex™ and Typhidot® tests for typhoid fever diagnosis in a community clinic in urban Bangladesh is low.