The HUS1B promoter is hypomethylated in the placentas of low-birth-weight infants
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- 作者：Janette Mareska Rumbajana ; b ; Yuko Yamaguchic ; Kazuhiko Nakabayashic ; Ken Higashimotoa ; Hitomi Yatsukia ; Kenichi Nishiokaa ; Kentaro Matsuokad ; Shigehisa Aokie ; Shuji Todae ; Satoru Takedaf ; Hiroyuki Sekig ; Izuho Hatadah ; Kenichiro Hatac ; Hidenobu Soejimaa ; soejimah@cc.saga-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Keiichiro Joha ; joh@cc.saga-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：LBW ; low-birth-weight ; NBW ; normal-birth-weight ; SGA ; small-for-gestational-age ; AGA ; appropriate-for-gestational-age ; MIAMI ; microarray-based integrated analysis of methylation by isoschizomers ; COBRA ; combined bisulfite restriction analysis ; 5Aza-dC ; 5-aza-2&prime ; -deoxycytidine ; PIH ; pregnancy-induced hypertension ; PCR ; polymerase chain reaction ; SD ; standard deviation ; TSS ; transcription start site
- 刊名：Gene
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：583
- 期：2
- 页码：141-146
- 全文大小：453 K
文摘
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The promoter of the HUS1B gene was highly methylated in human placentas.
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The promoter of the HUS1B gene was hypomethylated in three of 86 placentas from LBW infants.
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The HUS1B expression was induced by hypomethylation of the gene promoter in trophoblastic cell lines.