Serum adiponectin level is correlated with the size of HDL and LDL particles determined by high performance liquid chromatography

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• 作者：Kazumi Tsubakio-Yamamoto^a ; Taizo Sugimoto^b ; Makoto Nishida^c ; Rieko Okano^d ; Yasumasa Monden^e ; Rika Kitazume-Taneike^a ; Taiji Yamashita^a ; Hajime Nakaoka^a ; Ryota Kawase^a ; Miyako Yuasa-Kawase^a ; Miwako Inagaki^a ; Kazuhiro Nakatani^a ; Daisaku Masuda^a ; Tohru Ohama^a ; Akifumi Matsuyama^f ; Yumiko Nakagawa-Toyama^c ; Masato Ishigami^g ; Issei Komuro^a ; Shizuya Yamashita^a ; ^{shizu@imed2.med.osaka-u.ac.jp}
• 关键词：High density lipoprotein ; Low density lipoprotein ; Adiponectin ; HPLC ; 6 Insulin sensitivity
• 刊名：Metabolism
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：61
• 期：12
• 页码：1763-1770
• 全文大小：235 K

文摘

Objective

Adiponectin (APN) improves insulin resistance and prevents atherosclerosis, and HDL removes cholesterol from atherosclerotic lesions. We have demonstrated that serum HDL-cholesterol (HDL-C) and APN concentrations are positively correlated and that APN accelerates reverse cholesterol transport (RCT) by increasing HDL synthesis in the liver and cholesterol efflux from macrophages. We previously reported that APN reduced apolipoprotein (apo) B secretion from the liver. It is well-known that insulin resistance influences the lipoprotein profile. In this study, we investigated the clinical significance of APN levels and insulin resistance in lipoprotein metabolism.

Material/method

We investigated the correlation between serum APN concentration, HOMA-R, the lipid concentrations and lipoprotein particle size by high-performance liquid chromatography (HPLC) in 245 Japanese men during an annual health checkup.

Results

Serum APN level was positively correlated with the cholesterol content in large LDL and HDL particles, but inversely correlated with the cholesterol content in large VLDL and small LDL particles. HOMA-R was negatively correlated with the cholesterol content in large LDL and HDL particles and positively correlated with the cholesterol content in large VLDL and small LDL particles. By multivariate analysis, APN was correlated with the particle size of LDL-C and HDL-C independently of age, BMI and HOMA-R.

Conclusions

APN may be associated with the formation of both HDL and LDL particles, reflecting the enhancement of RCT and the improvement in TG-rich lipoprotein metabolism and insulin resistance.