A multicenter study of the early detection of synaptic dysfunction in Mild Cognitive Impairment using Magnetoencephalography-derived functional connectivity
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- 作者：Fernando Maestú ; PhDa ; ; Jose-Maria Peñ ; a ; PhDa ; Pilar Garcé ; s ; MSa ; Santiago Gonzá ; lez ; PhDa ; Ricardo Bajo ; PhDa ; Anto Bagic ; MD ; PhDb ; Pablo Cuesta ; MSa ; Michael Funke ; MDc ; Jyrki P. Mä ; kelä ; MDd ; Ernestina Menasalvas ; PhDa ; Akinori Nakamura ; MDe ; Lauri Parkkonen ; PhDf ; g ; Maria E. Ló ; pez ; PhDa ; Francisco del Pozo ; PhDa ; Gustavo Sudre ; PhDh ; Edward Zamrini ; MDi ; Eero Pekkonen ; MDj ; Richard N. Henson ; PhDk ; James T. Becker ; PhDb ; l ; m ; Magnetoencephalography International Consortium of Alzheimer's Disease1
- 关键词：Magnetoencephalography ; Mild Cognitive Impairment ; Functional connectivity ; Data mining ; Machine learning ; Synaptic dysfunction ; Multicenter study
- 刊名：NeuroImage: Clinical
- 出版年：2015
- 出版时间：2015
- 年：2015
- 卷：9
- 期：Complete
- 页码：103-109
- 全文大小：729 K
文摘
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Across centers reliable abnormalities in the neuronal network organization of MCI patients
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These findings are consistent with the view that AD may, in its earliest stages, represent a disconnection syndrome.
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A high rate of classification accuracy in a blind study, especially for individuals who were cognitively normal
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All these suggest that MEG may be a useful marker of preclinical synaptic disruption.
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The hypersynchronization found in MCI patients may represent a compensatory response.