Destruction of polylactic acid microcapsules under ultrasound irradiation

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• 作者：Hiraku Tabata ; Yukako Kato ; Shu Suematsu ; Kenji Yoshida ; Daisuke Koyama ; Kentaro Nakamura ; Yoshiaki Watanabe
• 关键词：Biocompatible harder shell ; Hollow microcapsule ; Destruction characteristics
• 刊名：Applied Acoustics
• 出版年：April, 2014
• 年：2014
• 卷：78
• 期：Complete
• 页码：89-91
• 全文大小：1158 K

文摘

Hollow microcapsules have been considered for potential applications as drug or gene carriers. This paper describes an investigation into the mechanical properties of microcapsules with a biocompatible polylactic acid (PLA) shell that can be destroyed using ultrasound irradiation. The microcapsules had a radius of 1 to 25 渭m and a shell thickness of 100 nm to 3 渭m, and their response to ultrasound pulses with a center frequency of 700 kHz to 2 MHz was investigated. It was found that approximately 50% of capsules with a radius of 20 渭m were destroyed using pulses with a pressure amplitude of 50 kPa and a frequency of 700 kHz, which is close to the resonance frequency of the capsules.