Evaluation of characteristics and degree of remodeling in coronary atherosclerotic lesions by 64-detector multislice computed tomography (MSCT)

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• 作者：Muhei Tanaka ; Ki-ichiro Tomiyasu ; Michiaki Fukui ; Satoshi Akabame ; Yoshiko Kobayashi-Takenaka ; Koji Nakano ; Mayuko Kadono ; Goji Hasegawa ; Yohei Oda ; Naoto Nakamura
• 关键词：MSCT ; Remodeling ; Hs-CRP ; UA ; Atherosclerosis
• 刊名：Atherosclerosis
• 出版年：2009
• 出版时间：April 2009
• 年：2009
• 卷：203
• 期：2
• 页码：436-441
• 全文大小：548 K

文摘

Background

Multislice computed tomography (MSCT) permits reliable imaging of not only the coronary artery lumen but also vessel wall. It is assumed that both lipid-rich plaques and those that display positive remodeling are more prone to rupture and erosion with subsequent coronary events. The purpose of this study was to assess the correlation between the characteristics of coronary arteries by MSCT and several measures of coronary heart disease (CHD) risk.

Methods

This study consisted of 424 consecutive participants who received MSCT and coronary angiography (CAG). We assessed coronary artery findings including coronary artery calcification (CAC), degree of remodeling and narrowing of lumen and characteristics including uric acid (UA) and high-sensitivity C-reactive protein (hs-CRP). Statistical analyses were conducted for four subgroups classified by the presence of significant stenosis and positive remodeling.

Results

Hs-CRP was 2.10 ± 2.70 mg/L in positive remodeling (+) and stenosis (+) group (PS), 1.05 ± 0.97 mg/L in positive remodeling (−) and stenosis (+) group (nPS), 0.94 ± 0.88 mg/L in positive remodeling (+) and stenosis (−) group (PnS) and 0.44 ± 0.49 mg/L in positive remodeling (−) and stenosis (−) group (nPnS). The results of logistic regression analysis showed that hs-CRP was higher in PS compared with the other groups (p < 0.001) and higher in nPS and PnS compared with nPnS (p < 0.05).

Conclusions

Regardless of significant stenosis, positive remodeling by MSCT correlates to the increase of hs-CRP.