Evaluation of a single-dose PIGRET assay for acetaminophen in rats compared with the RBC Pig-a assay
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- 作者：Yuta Suzuki ; suzuki-yuta@bozo.co.jp ; Ken Goto ; Yoshihiro Nakayama ; Masatoshi Saratani ; Takuya Takata ; Takezo Okamoto ; Shuzo Okazaki
- 关键词：Pig-a assay ; Mutagenicity ; Reticulocyte ; Genotoxicity
- 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：811
- 期：Complete
- 页码：16-20
- 全文大小：344 K
- 卷排序：811
文摘
Acetaminophen has no mutagenicity under the conditions of this study. The Pig-a MF in the ENU group was time-dependently increased in the RBC Pig-a assay. The Pig-a MF in the ENU group showed high values from week 1 in the PIGRET assay. The PIGRET assay can detect mutagenicity of ENU earlier than the RBC Pig-a assay.