Encapsulating Peritoneal Sclerosis

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• 作者：Helen Alston ; MRCP^⁎ ; Stanley Fan ; MD ; FRCP^⁎ ; ^{s.fan@qmul.ac.uk} ; Masaaki Nakayama ; MD ; PhD^&dagger ;
• 关键词：Encapsulating peritoneal sclerosis ; peritoneal membrane ; peritoneal dialysis ; EPS
• 刊名：Seminars in Nephrology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：37
• 期：1
• 页码：93-102
• 全文大小：1331 K
• 卷排序：37

文摘

Encapsulating peritoneal sclerosis (EPS) is a rare but serious complication of peritoneal dialysis. In this review, we describe the clinical picture and histologic changes to the peritoneal membrane that are associated with EPS and provide an update on current diagnosis and management. We also discuss the recent studies that have suggested that the use of more biocompatible solutions containing lower concentrations of glucose degradation product that often are pH neutral in combination with a change in clinical practice (reducing glucose exposure and monitoring peritoneal membrane function) might ameliorate peritoneal degeneration, reduce the incidence of EPS, and minimize the severity of the disease.