Anti-allodynic effect of mangiferin in neuropathic rats: Involvement of nitric oxide-cyclic GMP-ATP sensitive K<sup>+sup> channels pathway and serotoninergic system
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- 作者：Antonio Espinosa de los Monteros-Zuñ ; iga<sup>asup> ; Teresa Izquierdo<sup>asup> ; Geovanna Nallely Quiñ ; onez-Bastidas<sup>asup> ; Hé ; ctor Isaac Rocha-Gonzá ; lez<sup>bsup> ; Beatriz Godí ; nez-Chaparro<sup>asup><sup> ; sup><sup>bgodinez@correo.xoc.uam.mxsup>
- 关键词：Mangiferin ; Neuropathic pain ; Nitric oxide ; Potassium channels ; Serotonergic receptors
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：2016
- 出版时间：November-December 2016
- 年：2016
- 卷：150-151
- 期：Complete
- 页码：190-197
- 全文大小：707 K
- 卷排序：150
文摘
Mangiferin reduced SNL-induced tactile allodynia. Mangiferin produces its effect by activation of spinal 5-HT1A/1B/1D/5A receptors. The NO-cGMP-ATP-sensitive K+ channels pathway is implicated in mangiferin effects. The activity of mangiferin in the SNL model was independent of the opioid system.