Tension pneumopericardium following a traffic accident

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• 作者：Shuichi Hagiwara ; Takashi Ogino ; Akira Isaka ; Noriyuki Ihara ; Mitunobu Nakamura ; Tarou Nameki ; Yuga Takahashi ; Yuichi Iino
• 关键词：tacrolimus (FK 506) ; IMX Abbott ; é ; valuation analytique
  Author Keywords ; tacrolimus (FK 506) ; IMX Abbott ; analytical evaluation
• 刊名：Injury Extra
• 出版年：2007
• 出版时间：December 2007
• 年：2007
• 卷：38
• 期：12
• 页码：436-438
• 全文大小：141 K

文摘

Tacrolimus (FK 506) is a macrolide antibiotic which has immunosuppressive properties 50–100 times more potent than cyclosporine. It is used in prophylaxis of allograft rejection. Tacrolimus blocks the production of interleukin 2, thereby inhibiting T lymphocyte proliferation. Tacrolimus is metabolized solely in the liver and the metabolites are primarily excreted in the bile. Because of its multiple adverse effects (nephrotoxicity, neurotoxicity) monitoring of tacrolimus blood concentration is required. We used a microparticle enzyme immunoassay (MEIA) on the IMX analyser (Abbott). This kit allowing determination of tacrolimus in whole blood, shows acceptable analytic performances: within and between-run CVs of 10 and 12 % respectively, good linearity and sensitivity of 3 μg/l. The tacrolimus test provides a rapid and accurate mean for monitoring tacrolimus therapy.