Renal sympathetic denervation for treatment of patients with atrial fibrillation: Reappraisal of the available evidence

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• 作者：Wail Nammas ; PhD^⁎ ; Juhani K.E. Airaksinen ; PhD^&dagger ; ; Tuomas Paana ; MD^⁎ ; Pasi P. Karjalainen ; PhD^⁎ ; ^{pasi.karjalainen@satshp.fi" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Renal sympathetic denervation ; Arial fibrillation
• 刊名：Heart Rhythm
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：13
• 期：12
• 页码：2388-2394
• 全文大小：480 K

文摘

Afferent renal sympathetic nerve signaling regulates central sympathetic outflow. In this regard, renal sympathetic denervation has emerged as a novel interventional strategy for treatment of patients with resistant hypertension. Despite the disappointing results of the Simplicity HTN-3 randomized controlled trial, promoters of renal denervation argue that the negative results were due to ineffective denervation technique and poor patient selection. Yet, long-term “pathologic” increase of efferent sympathetic nerve activity is observed in many chronic disease states characterized by sympathetic overactivity, such as arrhythmia, heart failure, insulin resistance, and chronic kidney disease. In this review, we highlight the contemporary evidence on the safety/efficacy of renal denervation in the treatment of patients with atrial fibrillation.