Surface expression of the Anoctamin-1 (ANO1) channel is suppressed by protein-protein interactions with β-COP
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- 作者：Young-Sun Lee<sup>asup><sup> ; sup><sup>bsup> ; Yeonju Bae<sup>asup> ; Nammi Park<sup>asup> ; Jae Cheal Yoo<sup>asup> ; Chang-Hoon Cho<sup>asup> ; Kanghyun Ryoo<sup>asup> ; Eun Mi Hwang<sup>bsup><sup> ; sup><sup>csup><sup> ; sup><sup>emhwang@kist.re.kr" class="auth_mail" title="E-mail the corresponding authorsup> ; Jae-Yong Park<sup>asup><sup> ; sup><sup>jaeyong68@korea.ac.kr" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：ANO1 ; β-COP ; Surface expression ; Yeast two-hybrid screening ; Protein&ndash ; protein interactions ; U251 glioblastoma cells
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：24 June 2016
- 年：2016
- 卷：475
- 期：2
- 页码：216-222
- 全文大小：1197 K
文摘
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β-COP directly binds to the N-terminus of ANO1.
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Surface expression of ANO1 is suppressed by β-COP in a heterologous system.
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The overexpression of β-COP reduced endogenous ANO1 surface expression in U251 cells.
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Knockdown of β-COP enhanced endogenous ANO1 surface expression in U251 cells.