Mitochondria-targeting “Nanoheater” for enhanced photothermal/chemo-therapy

详细信息    查看全文

• 作者：Si Chen^a ; ^b ; ¹ ; Qi Lei^a ; ¹ ; Wen-Xiu Qiu^a ; Li-Han Liu^a ; Di-Wei Zheng^a ; Jin-Xuan Fan^a ; Lei Rong^a ; Yun-Xia Sun^a ; ^{yx-sun@whu.edu.cn} ; Xian-Zheng Zhang^a ; ^{xz-zhang@whu.edu.cn}
• 关键词：Gold nanostar ; Mitochondria-targeting ; Photothermal therapy ; Combination therapy ; Pro-apoptotic peptide
• 刊名：Biomaterials
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：117
• 期：Complete
• 页码：92-104
• 全文大小：4142 K
• 卷排序：117

文摘

In this work, mitochondria-targeting gold nanostar (AuNS) and anticarcinogen DOX were co-encapsulated in hyaluronic acid (HA) protective shell for tumor-targeting synergistic photothermal/chemo-therapy. Cationic peptide R8 and mitochondria-targeting pro-apoptotic peptide TPP-KLA were co-decorated on AuNS to form AuNS-pep via Au-S bonds. Then, electronegative HA was further coated on the surface via electrostatic interaction for cancer cell targeting. During the coating process, DOX was also introduced via electrostatic interaction to obtain a versatile nanoplatform AuNS-pep/DOX@HA. It was found that the nanoplatform could be internalized into tumor cells via CD44 receptor-mediated recognition. Followed digestion by hyaluronidase (HAase), the therapeutic nanoplatform was able to release DOX for chemotherapy and mitochondria-targeting nanoheater AuNS-pep for near infrared (NIR) light triggered subcellular photothermal therapy (PTT). This tumor-targeting nanoplatform AuNS-pep/DOX@HA displayed prominent non-resistant or resistant tumor inhibition both in vitro and in vivo.