- 作者：Wylie Burke ; Susan Brown Trinidad ; Nancy A. Press
- 关键词：Personalized medicine ; Genetics ; Genomics ; Pharmacogenomics ; Prostate cancer ; Health technology assessment
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：February, 2014
- 年：2014
- 卷：32
- 期：2
- 页码：193-197
- 全文大小：141 K
Summary
Objectives
Genomic information has been promoted as the basis for 鈥減ersonalized鈥?health care. We considered the benefits provided by genomic testing in context of the concept of personalized medicine.Materials and Methods
We evaluated current and potential uses of genomic testing in health care, using prostate cancer as an example, and considered their implications for individualizing or otherwise improving health care.
Results and Conclusions
Personalized medicine is most accurately seen as a comprehensive effort to tailor health care to the individual, spanning multiple dimensions. While genomic tests will offer many potential opportunities to improve the delivery of care, including the potential for genomic research to offer opportunities to improve prostate cancer screening and treatment, such advances do not in themselves constitute a paradigm shift in the delivery of health care. Rather, personalized medicine is based on a partnership between clinician and patient that utilizes shared decision making to determine the best health care options among the available choices, weighing the patient鈥檚 personal values and preferences together with clinical findings. This approach is particularly important for difficult clinical decisions involving uncertainty and trade-offs, such as those involved in prostate cancer screening and management. The delivery of personalized medicine also requires adequate health care access and assurance that basic health needs have been met. Substantial research investment will be needed to identify how genomic tests can contribute to this effort.