The association between serum β-hCG on day 24 of pregnancy and ongoing pregnancy in frozen embryo transfer cycles

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• 作者：Xin Chen^a ; ¹ ; Yuan Huang^b ; ¹ ; Ping-Ping Guo^a ; De-Sheng Ye^a ; Li-Juan Xu^c ; Shi-Ling Chen^a ; ^{chensl_92@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：β-Subunit of human chorionic gonadotropin (β-hCG) ; Frozen embryo transfer ; Ongoing pregnancy ; Pregnancy outcome
• 刊名：International Journal of Gynecology and Obstetrics
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：134
• 期：3
• 页码：278-281
• 全文大小：280 K

文摘

To determine the relationship between serum levels of the β-subunit of human chorionic gonadotropin (β-hCG) on day 24 of pregnancy during a frozen embryo transfer (FET) cycle and ongoing pregnancy.

Methods

In a retrospective cohort study, data were reviewed from women aged 38 years or younger who underwent a FET cycle at Nanfang Hospital, Guangzhou, China, from January 2013 to December 2014. Inclusion criteria were use of hormone-replacement therapy to achieve an endometrial thickness of 8 mm or more, and at least two surviving embryos. Serum β-hCG on day 24 of pregnancy was assessed in relation to ongoing pregnancy at 12 weeks.

Results

Overall, 217 patients who underwent 248 FET cycles were included. The only measure that differed between cycles with (n = 112) and without (n = 136) ongoing pregnancy was β-hCG level on day 24 of pregnancy (73.0 ± 65.8 vs 19.4 ± 34.5 mIU/mL; P < 0.001). Classification tree analysis showed that women with day-24 β-hCG levels higher than 26.6 mIU/mL had a 75.8% likelihood of ongoing pregnancy. In receiver operating characteristic curve analysis, the corresponding area under curve was 0.845 (95% confidence interval 0.795–0.895).

Conclusion

A maternal serum β-hCG level higher than 26.6 mIU/mL was predictive of ongoing pregnancy at 12 weeks.