Pre-clinical investigation of the modulation of quetiapine plasma pharmacokinetics and tissues biodistribution by lipid-core nanocapsules
详细信息 查看全文
- 作者：Fernando Carreñ ; o fer.carreno@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Karina Paese karinapaese@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Carolina Miranda Silva silvacarolmiranda@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Sí ; lvia S. Guterres silvia.guterres@ufrgs.br" class="auth_mail" title="E-mail the corresponding author ; Teresa Dalla Costa ; teresadc@farmacia.ufrgs.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Quetiapine ; LC/UV method ; Lipid-core nanocapsules ; Pre-clinical pharmacokinetics ; Biodistribution
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：5 February 2016
- 年：2016
- 卷：119
- 期：Complete
- 页码：152-158
- 全文大小：753 K
文摘
- •
A LC-UV method was validated to quantify quetiapine in rat plasma, brain and liver.
- •
Nanoencapsulation changed plasma PK and tissue biodistribution of the drug.
- •
Nanocapsules protected hepatic metabolism of QTP and increased its brain exposure.