Liquid crystals and emulsions in the formulation of drug carriers

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• 作者：Patrick Saulnier ; Nicolas Anton ; Bé ; atrice Heurtault ; Jean-Pierre Benoit
• 关键词：Nanoparticles ; Liquid crystals ; Phase inversion ; Bicontinuous systems ; Fast dilution
• 刊名：Comptes Rendus Chimie
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：11
• 期：3
• 页码：221-228
• 全文大小：860 K

文摘

Targetting an encapsulated drug towards a diseased organ, with the possibility to control its release at the right place and at the right time, is one among numerous questions asked to the new nanotechnologies. We present a partial answer with the example of recently elaborated lipidic nanocapsules. Liquid crystals play a role in the preparation techniques, and possibly in the delivery mechanisms of the active principle in situ. We also know that liquid crystalline behaviours are involved at the membrane level and are essential in the cell machinery. Drug nanocarriers could find their way, as do viruses, in the liquid crystalline context of cell organization.