Pressure-driven flow control system for nanofluidic chemical process
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- 作者：Eiichiro Tamaki ; Akihide Hibara ; Haeng-Boo Kim ; Manabu Tokeshi ; Takehiko Kitamori
- 关键词：Nanofluidics ; Nanochannel ; Microchip ; Pressure-driven flow ; Nanochemical process ; Backpressure
- 刊名：Journal of Chromatography A
- 出版年：2006
- 出版时间：29 December 2006
- 年：2006
- 卷：1137
- 期：2
- 页码：256-262
- 全文大小：1134 K
文摘
We developed a novel flow control system for a nanofluidic chemical process. Generally, flow control in nanochannels is difficult because of its high-pressure loss with very small volume flow rate. In our flow control method, liquid pressure in a microchannel connected to the nanochannels is regulated by utilizing a backpressure regulator. The flow control method was verified by using simple structured microchip, which included parallel nanochannels. We found that the observed flow rate was three times lower than the value expected from Hagen–Poiseuille's equation. That implied a size-dependent viscosity change in the nanochannels. Then, we demonstrated mixing of two different fluorescent solutions in a Y-shaped nanochannel and also a proton exchange reaction in the Y-shaped nanochannel. The flow control method will contribute to further integration of nanochemical systems.