Nanoparticles for multi-modality cancer diagnosis: Simple protocol for self-assembly of gold nanoclusters mediated by gadolinium ions

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• 作者：Wenxiu Hou^a ; ^b ; ¹ ; Fangfang Xia^a ; ¹ ; Gabriel Alfranca^a ; ^d ; Hao Yan^a ; Xiao Zhi^a ; Yanlei Liu^a ; ^b ; Chen Peng^c ; ^{cpengrr@tongji.edu.cn} ; Chunlei Zhang^a ; ^{chunleizhang@sjtu.edu.cn} ; Jesus Martinez de la Fuente^a ; ^d ; Daxiang Cui^a ; ^{dxcui@sjtu.edu.cn}
• 关键词：Gold nanoclusters (GNCs) ; Gd3+ ions ; Assembly ; Multi-modality imaging ; Diagnosis
• 刊名：Biomaterials
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：120
• 期：Complete
• 页码：103-114
• 全文大小：3420 K
• 卷排序：120

文摘

It is essential to develop a simple synthetic strategy to improve the quality of multifunctional contrast agents for cancer diagnosis. Herein, we report a time-saving method for gadolinium (Gd3+) ions-mediated self-assembly of gold nanoclusters (GNCs) into monodisperse spherical nanoparticles (GNCNs) under mild conditions. The monodisperse, regular and colloidal stable GNCNs were formed via selectively inducing electrostatic interactions between negatively-charged carboxylic groups of gold nanoclusters and trivalent cations of gadolinium in aqueous solution. In this way, the Gd3+ ions were chelated into GNCNs without the use of molecular gadolinium chelates. With the co-existence of GNCs and Gd3+ ions, the formed GNCNs exhibit significant luminescence intensity enhancement for near-infrared fluorescence (NIRF) imaging, high X-ray attenuation for computed tomography (CT) imaging and reasonable r1 relaxivity for magnetic resonance (MR) imaging. The excellent biocompatibility of the GNCNs was proved both in vitro and in vivo. Meanwhile, the GNCNs also possess unique NIRF/CT/MR imaging ability in A549 tumor-bearing mice. In a nutshell, the simple and safe GNCNs hold great potential for tumor multi-modality clinical diagnosis.