Layered chitosan-collagen hydrogel/aligned PLLA nanofiber construct for flexor tendon regeneration
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- 作者：S. Deepthi1 ; M. Nivedhitha Sundaram1 ; J. Deepti Kadavan1 ; R. Jayakumar ; rjayakumar@aims.amrita.edu" class="auth_mail" title="E-mail the corresponding author ; jayakumar77@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chitosan-collagen hydrogel ; PLLA nanofibers ; Alginate ; Tendon regeneration ; Peritendinous adhesion
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 November 2016
- 年：2016
- 卷：153
- 期：Complete
- 页码：492-500
- 全文大小：3840 K
文摘
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Layered chitosan-collagen hydrogel/aligned PLLA nanofiber construct was developed.
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The developed construct mimics native tendon architecture.
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Alginate coating suppresses peritendinous adhesion by reducing protein adsorption.
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Enhanced tenocytes growth was seen along the fibers and chitosan-collagen hydrogel.
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The developed tendon construct would be suitable for flexor tendon regeneration.