Synergistic nanomedicine by combined gene and photothermal therapy

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• 作者：Jinhwan Kim^a ; ¹ ; Jihoon Kim^b ; ¹ ; Cherlhyun Jeong^c ; ^{che.jeong@kist.re.kr" class="auth_mail" title="E-mail the corresponding author} ; Won Jong Kim^a ; ^b ; ^{wjkim@postech.ac.kr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：DNA ; deoxyribonucleic acid ; RNA ; ribonucleic acid ; EPR ; enhanced permeation and retention ; PEI ; polyethylenimine ; PEG ; polyethylenglycol ; NIR ; near infrared ; AuNP ; gold nanoparticle ; AgNP ; silver nanoparticle ; CNT ; carbon nanotube ; TMDC ; transition metal dichalcogenide ; AuNC ; gold nanocluster ; pDNA ; plasmid DNA ; siRNA ; small interfering RNA ; Bcl-2 ; B-cell lymphoma 2 ; AuNR ; gold nanorod ; PKM2 ; pyruvate kinase 2 ; SWNT ; single-walled carbon nanotube ; hTERT ; human telomerase reverse transcriptase ; S
• 刊名：Advanced Drug Delivery Reviews
• 出版年：2016
• 出版时间：1 March 2016
• 年：2016
• 卷：98
• 期：Complete
• 页码：99-112
• 全文大小：1687 K

文摘

To date, various nanomaterials with the ability for gene delivery or photothermal effect have been developed in the field of biomedicine. The therapeutic potential of these nanomaterials has raised considerable interests in their use in potential next-generation strategies for effective anticancer therapy. In particular, the advancement of novel nanomedicines utilizing both therapeutic strategies of gene delivery and photothermal effect has generated much optimism regarding the imminent development of effective and successful cancer treatments. In this review, we discuss current research progress with regard to combined gene and photothermal therapy. This review focuses on synergistic therapeutic systems combining gene regulation and photothermal ablation as well as logically designed nano-carriers aimed at enhancing the delivery efficiency of therapeutic genes using the photothermal effect. The examples detailed in this review provide insight to further our understanding of combinatorial gene and photothermal therapy, thus paving the way for the design of promising nanomedicines.