Biomimetic HDL nanoparticle mediated tumor targeted delivery of indocyanine green for enhanced photodynamic therapy
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- 作者：Yazhe Wanga ; Cheng Wanga ; Yang Dinga ; Jing Lib ; Min Lia ; Xiao Lianga ; Jianping Zhoua ; zhoujp60@163.com" class="auth_mail" title="E-mail the corresponding author ; Wei Wanga ; wangcpu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Biomimetic nanoparticle ; High density lipoprotein ; Photodynamic therapy ; Tumor targeting ; Stability
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：533-540
- 全文大小：2194 K
文摘
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Indocyanine green loaded biomimetic HDL nanoparticle was successfully prepared and characterized.
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The biomimetic nanoparticle showed photoprotection effect and light-triggered controlled release feature.
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The prepared nanoparticle presented enhanced cellular uptake and ROS generation in vitro.
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In vivo studies demonstrated superior tumor targeting and internalization of the biomimetic HDL nanoparticle.