Chitosan-coupled solid lipid nanoparticles: Tuning nanostructure and mucoadhesion

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• 作者：Giuseppina Sandri^a ; Simona Motta^b ; Maria Cristina Bonferoni^a ; Paola Brocca^b ; Silvia Rossi^a ; Franca Ferrari^a ; Valeria Rondelli^b ; Laura Cantù ; ^b ; ^{laura.cantu@unimi.it} ; Carla Caramella^a ; Elena Del Favero^b
• 关键词：Solid lipid nanoparticles ; Chitosan ; Structural analysis ; Mucoadhesion
• 刊名：European Journal of Pharmaceutics and Biopharmaceutics
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：110
• 期：Complete
• 页码：13-18
• 全文大小：715 K
• 卷排序：110

文摘

Solid Lipid Nanoparticles (SLNs) composed of biodegradable physiological lipids have been widely proposed as efficient drug delivery systems, also for ophthalmic administration. Recently, chitosan-associated-SLNs have been developed to further improve the residence time of these colloidal systems in the precorneal area by means of mucoadhesive interaction. In the present study, a one-step preparation protocol was used aiming both at scale-up ease and at stronger coupling between chitosan and SLNs. The resulting particles were chitosan associated-SLNs (CS-SLNs). These nanoparticles were characterized, as compared to both the chitosan-free and the usual chitosan-coated ones, by applying a multi-technique approach: light, neutron and X-ray scattering, Zeta-potential, AFM, calorimetry. It was assessed that, while keeping the features of nano-size and surface-charge required for an efficient vector, these new nanoparticles display a strong and intimate interaction between chitosan and SLNs, far more settled than the usual simple coverage. Moreover, this one-step preparation method allows to obtain a strong and intimate interaction between chitosan and SLNs, firmer than the usual simple coating. This confers to the CS-SLNs an improved mucoadhesion, opening the way for a high-performing ophthalmic formulation.