Cytotoxicity of folic acid conjugated hollow silica nanoparticles toward Caco2 and 3T3 cells, with and without encapsulated DOX
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- 作者：Kunal Patela ; Behin Sundara Rajb ; Yan Chenb ; Xia Loua ; x.lou@curtin.edu.au" class="auth_mail" title="E-mail the corresponding author ; lizilou7854@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hollow silica nanoparticles ; Cytotoxicity ; Drug delivery ; Doxorubicin hydrochloride
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：140
- 期：Complete
- 页码：213-222
- 全文大小：2122 K
文摘
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Hollow silica nanoparticles with and without conjugated folic acid were synthesized.
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Both types of particles showed selective inhibition of Caco2 over 3T3 cells.
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DOX loaded hollow silica folate particles further enhanced the selective inhibition.
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Free DOX showed comparatively limited selectivity and toxicity.
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Conjugated folic acid increased the viability of both 3T3 and Caco2 cells.