Simultaneous determination of l-ascorbic acid, dopamine and uric acid with gold nanoparticles-¦Â-cyclodextrin-graphene-modified electrode by square wave voltammetry

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• 作者：Xianqing Tian^a ; Changming Cheng^b ; Hongyan Yuan^b ; Juan Du^a ; Dan Xiao^a ; ^b ; ^{xiaodan@scu.edu.cn} ; Shunping Xie^c ; Martin M.F. Choi^c ; ¹ ; ^{mfchoi@hkbu.edu.hk}
• 关键词：Graphene ; ¦Â-Cyclodextrin ; Electroanalysis ; l-Ascorbic acid ; Dopamine ; Uric acid
• 刊名：Talanta
• 出版年：2012
• 出版时间：15 May, 2012
• 年：2012
• 卷：93
• 期：Complete
• 页码：79-85
• 全文大小：954 K

文摘

Graphene decorated with gold nanoparticles (AuNPs-¦Â-CD-Gra) has been synthesized by in situ thermal reduction of graphene oxide and HAuCl₄ with ¦Â-cyclodextrin (¦Â-CD) under alkaline condition. The AuNPs-¦Â-CD-Gra product was well characterized by infrared spectroscopy, X-ray powder diffraction, scanning electron microscopy, high-resolution transmission electron microscopy, and selected area electron diffraction. This material was used to fabricate an AuNPs-¦Â-CD-Gra-modified glassy carbon electrode (GCE) which showed excellent electro-oxidation of l-ascorbic acid (AA), dopamine (DA) and uric acid (UA) in 0.10 M NaH₂PO₄-HCl buffer solution (pH 2.0) by square wave voltammetry (SWV). Three well-resolved oxidation peaks of AA and DA and UA were obtained. The AuNPs-¦Â-CD-Gra/GCE exhibits linear responses to AA, DA and UA in the ranges 30-2000, 0.5-150 and 0.5-60 ¦ÌM, respectively. The detection limits (based on S/N = 3 and preconcentration time = 3.0 min) for AA, DA and UA are 10, 0.15 and 0.21 ¦ÌM, respectively. The AuNPs-¦Â-CD-Gra/GCE has been successfully applied to determine UA in human urine with satisfactory results. Our work provides a simple, convenient and green route to synthesize AuNPs on Gra which is potentially useful in electroanalysis.