A molecularly imprinted sensor based on ¦Â-cyclodextrin incorporated multiwalled carbon nanotube and gold nanoparticles-polyamide amine dendrimer nanocomposites combining with water-soluble chitosan derivative for the detection of chlortetracycline

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• 作者：Wenjing Lian^a  ; [Author Vitae] ; Jiadong Huang^b  ; [Author Vitae] ; Jinghua Yu^a  ; [Author Vitae] ; Xiuming Zhang^a  ; [Author Vitae] ; Qing Lin^a  ; [Author Vitae] ; Xiaorui He^a  ; [Author Vitae] ; Xianrong Xing^a  ; [Author Vitae] ; Su Liu^c ; ^{stu_lius@ujn.edu.cn}  ; [Author Vitae]
• 关键词：Molecularly imprinted polymers ; Chitosan derivative ; ¦Â-cyclodextrin-multiwalled carbon nanotube composites ; Gold nanoparticles-polyamide amine dendrimer nanocomposites ; Chlortetracycline detection
• 刊名：Food Control
• 出版年：2012
• 出版时间：August, 2012
• 年：2012
• 卷：26
• 期：2
• 页码：620-627
• 全文大小：800 K

文摘

We developed a molecularly imprinted electrochemical sensor based on gold electrode decorated by ¦Â-cyclodextrin (CD) incorporated multiwalled carbon nanotube, gold nanoparticles-polyamide amine dendrimer nanocomposites (Au-PAMAM) and chitosan derivative (CSDT) for selective and convenient determination of chlortetracycline (CTC). The electrochemical sensor was fabricated by stepwise modification of cyclodextrin-multiwalled carbon nanotube composites (CD-MWCNTs) and Au-PAMAM onto the gold electrode. The layer of MIPs was the outer layer of the electrochemical sensor. In this article, CSDT acted as functional monomer, and CTC as the template molecule. Cyclic voltammetry (CV) and amperometry were used to characterize the electrochemical behavior of the developed sensor. The linear range of the molecularly imprinted sensor was from 9.00?¡Á?10^? to 5.00?¡Á?10^??mol/L (from 0.0464?mg/kg to 25.767?mg/kg), with the limit of detection (LOD) of 4.954?¡Á?10^??mol/L (0.0255?mg/kg, S/N?=?3). The developed sensor showed high selectivity and excellent stability toward CTC. The results from real sample analysis confirmed the applicability of the sensor to quantitative analysis.