Nanoparticles decorated with proteolytic enzymes, a promising strategy to overcome the mucus barrier
详细信息 查看全文
- 作者：Irene Pereira de Sousaa ; Beatrice Cattozb ; Matthew D. Wilcoxc ; Peter C. Griffithsb ; Robert Dalglieshd ; Sarah Rogersd ; Andreas Bernkop-Schnü ; rcha ; andreas.bernkop@uibk.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mucus permeating nanoparticles ; Papain ; Bromelain ; Oral drug delivery ; Diffusion ; Enzyme functionalization
- 刊名：European Journal of Pharmaceutics and Biopharmaceutics
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：97
- 期：part_PA
- 页码：257-264
- 全文大小：1103 K
文摘
- •
Nanoparticles were formulated with papain and bromelain modified poly(acrylic acid).
- •
Inside from a nm to a μm length scale of particles mucus permeation ability is given.
- •
Particles bearing bromelain show higher permeation ability then papain particles.
- •
Bromelain particles exhibit the most relevant effect in altering mucus structure.
- •
Bromelain decorated particles can be exploited as oral drug delivery system.