Au-Ag-Au double shell nanoparticles-based localized surface plasmon resonance and surface-enhanced Raman scattering biosensor for sensitive detection of 2-mercapto-1-methylimidazole

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• 作者：Xue Liao ; Yanhua Chen ; Meihong Qin ; Yang Chen ; Lei Yang ; Hanqi Zhang ; Yuan Tian
• 关键词：Localized surface plasmon resonance (LSPR) ; Surface-enhanced Raman scattering (SERS) ; Au&ndash ; Ag&ndash ; Au double shell nanoparticles ; 2-Mercapto-1-methylimidazole (methimazole)
• 刊名：Talanta
• 出版年：15 December, 2013
• 年：2013
• 卷：117
• 期：Complete
• 页码：203-208
• 全文大小：1323 K

文摘

In this paper, Au-Ag-Au double shell nanoparticles were prepared based on the reduction of the metal salts HAuCl₄ and AgNO₃ at the surface of seed particles. Due to the synergistic effect between Au and Ag, the hybrid nanoparticles are particularly stable and show excellent performances on the detection of 2-mercapto-1-methylimidazole (methimazole). The binding of target molecule at the surface of Au-Ag-Au double shell nanoparticles was demonstrated based on both localized surface plasmon resonance (LSPR) and surface-enhanced Raman scattering (SERS) spectra. The LSPR intensity is directly proportional to the methimazole concentration in the range of 0.10-3.00脳10^鈭? mol L^鈭?. The SERS spectrum can be applied in identification of methimazole molecule. The LSPR coupled with SERS based on the Au-Ag-Au double shell nanoparticles would be very attractive for the quantitative determination and qualitative analysis of the analytes in medicines.