In vitro controlled release of antigen in dendritic cells using pH-sensitive liposome-polymeric hybrid nanoparticles
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- 作者：Yun Hua ; Zongmin Zhaoa ; Marion Ehrichb ; Kristel Fuhrmanc ; Chenming Zhanga ; chzhang2@vt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：PLGA nanoparticle ; pH-sensitive lipid ; Vaccine
- 刊名：Polymer
- 出版年：2015
- 出版时间：2 December 2015
- 年：2015
- 卷：80
- 期：Complete
- 页码：171-179
- 全文大小：2316 K
文摘
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A hybrid nanoparticle consisting of a pH sensitive lipid shell and a poly(lactic-co-glycolic) acid core was constructed.
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The hybrid NPs are stable and can minimize the release of enclosed antigens during circulation.
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The hybrid NPs can be internalized by dendritic cells (DC) readily.
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A burst release of antigens was observed upon internalization of the NPs by DCs.