Co-encapsulation of multi-lipids and polymers enhances the performance of vancomycin in lipid-polymer hybrid nanoparticles: In vitro and in silico studies
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- 作者：Nasreen Seedat ; Rahul S. Kalhapure ; Chunderika Mocktar ; Suresh Vepuri ; Mahantesh Jadhav ; Mahmoud Soliman ; Thirumala Govender ; govenderth@ukzn.ac.za" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vancomycin ; Lipid&ndash ; polymer ; Nanoparticle ; MRSA ; Antibacterial ; In silico
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：61
- 期：Complete
- 页码：616-630
- 全文大小：1510 K
文摘
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Vancomycin (VCM) loaded lipid polymer nanoparticles using various co-excipients were synthesized.
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Encapsulation efficiency (EE) increased the most from 27.8% to 69.3% with the addition of ALG.
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Drug release indicated that VCM-CHT had the best performance in sustained drug release of 36.1 ± 5.35% after 24h.
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The EE and drug release was further mechanistically explained using molecular modelling studies.
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All formulations exhibited sustained activity against both S.aureus and MRSA.