SPR Biosensors: Historical Perspectives and Current Challenges

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• 作者：Pranveer Singh ; ^{mailpranveer@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{pranveer11@rediffmail.com" class="auth_mail" title="E-mail the corresponding author}Author Vitae
• 关键词：Biosensors ; Kinetics ; Affinity ; Surface plasmons ; Nanoplasmonics ; Microfluidics
• 刊名：Sensors & Actuators: B. Chemical
• 出版年：2016
• 出版时间：28 June 2016
• 年：2016
• 卷：229
• 期：Complete
• 页码：110-130
• 全文大小：4949 K

文摘

SPR is a real-time, label-free measurement of binding kinetics and affinity. Success of SPR biosensor is evident by the growing number of commercially available instruments. In the current review, development in plasmon resonance techniques such as SPR, SPR-imaging (microscope, spectroscope, Electrochemical Impedance), nanoplasmonics and microfluidics, membrane proteins: receptor studies, sensors based on polarization and interferometery, PWR, SPR–MS, Signal locked SPR, FOPPR, Mid-IR SPR, trends in protein array technology and point-of-care (POC) testing over last decade are summarized. In addition, advancement over sensor configuration, mechanism and immobilization techniques are also discussed. Advantage and disadvantage of each methodology is provided along with some of the latest accomplishments.