Merging colloidal nanoplasmonics and surface plasmon resonance spectroscopy for enhanced profiling of multiple myeloma-derived exosomes
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- 作者：Giuseppe Di Notoa ; gdinoto87@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Antonella Bugattia ; Andrea Zendrinia ; Elena Laura Mazzoldia ; Alessandro Montanellib ; Luigi Caimia ; Marco Rusnatia ; Doris Ricottaa ; Paolo Bergesea ; paolo.bergese@unibs.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Multiple myeloma ; Exosome ; Nanoplasmonics ; Surface plasmon resonance spectroscopy
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：518-524
- 全文大小：1535 K
文摘
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Nano and surface plasmonics were used to probe multiple myeloma (MM) exosomes.
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Nanoplasmonics probed that MM patients count four folds more exosomes than healthy.
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Nanoplasmonic titration allowed for controlled SPR biosensing experiments.
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SPR biosensing showed that MM exosomes have a distinctive affinity for heparin.