This study highlights the potential of dentin conditioning with temporal-controlled dexamethasone releasing chitosan nanoparticle system (Dex-CSnp).
Conditioning of dentin with Dex-CSnp reversed the deleterious effects caused by endodontic irrigants on dentin.
Dentin conditioning with Dex-CSnp enhanced odontogenic differentiation potential of SCAP.
The proposed bioactive nanopolymeric system can be used for dentin conditioning to achieve spatial and temporal control in regenerative endodontics.