The research and development results of new anti-friction polymer nanocomposites based on polytetrafluoroethylene characterized with an increased wear resistance due to the polymer matrix with complex fillers-modifiers modification are presented in the paper. Fillers include micro- and nanoscale components of different nature and the particles geometry having specific surface and surface free energy high values. These factors provide the polymer matrix high-performance structural modification and significant increase in nanocomposites wear resistance in dry boundary friction.