Isoquinoline derivatives as potential acetylcholinesterase inhibitors
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- 作者：Sutthatip Markmee ; Somsak Ruchirawat ; Vilailak Prachyawarakorn ; Kornkanok Ingkaninan and Nantaka Khorana
- 关键词：Isoquinoline ; Acetylcholinesterase inhibitors ; Alzheimer’ ; s disease
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2006
- 出版时间：15 April 2006
- 年：2006
- 卷：16
- 期：8
- 页码：2170-2172
- 全文大小：105 K
文摘
Several bisbenzylisoquinoline alkaloid derivatives showed the inhibitory activity at acetylcholinesterase enzyme (AChE) in micromolar range. It is possible that monomeric moiety of bisbenzylisoquinoline alkaloid might be required for acetylcholinesterase enzyme inhibition. AChE inhibitory activity of related monomeric 1-benzylisoquinolines was examined by using Ellman colorimetric assay with galanthamine as a reference standard.